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KMID : 1191420120110010007
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Korean Journal of Optometry and Vision Science
2012 Volume.11 No. 1 p.7 ~ p.14
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Aging Effect on Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography in Korean
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Kwon Yong-Dae
Kang Shin-Hee
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Abstract
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Purpose: To investigate the relationship between peripapillary retinal nerve fiber layer (RNFL) thickness measurements by time domain optical coherence tomography (TD-OCT) in a normal Korean population and aging.
Methods: 470 eyes of 237 healthy Korean volunteers (age range 13∼82 years, mean age 43.0 years old) were enrolled in this clininical cross-sectional study. The peripapillary RNFL was measured by TD-OCT (Stratus OCT). The thickness of the peripallary RNFL was obtained at the 256 points of circular edge around the optic disc with diameter 3.4 mm. The relationship between peripapillary RNFL thickness and age was analyzed.
Results: The mean age was 42.95 years. The mean RNFL thickness of the healthy Korean people was 106.5±10.5?m. There was a significant negative correlation in average RNFL thickness with increasing age. In the nasal quadrant, there was no significant negative correlation with increasing age. At the scan points from 226 to 246 (8 o’clock direction), the RNFL thickness was decreased with age significantly. Among age groups, thirties group was disclosed most decreasing rate at 8 o’clock direction.
Conclusions: The RNFL thickness of normal Korean population appeared to decrease with increasing age especially in the inferotemporal and superotemporal portions. The property of RNFL thickness with a decreasing tendency of different degrees according to the area over time should be considered in diagnosis and follow up of glaucoma patient.
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KEYWORD
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Aging process, Optical coherence tomography, Retinal nerve fiber layer
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